RNA Details
Disease Name
diabetic nephropathy
Tissue
kidney
RNA Symbol
mir-133b
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
dual-luciferase reporter assay; immunohistochemistry etc.
Target
SIRT1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MiR-133b and miR-199b knockdown attenuate TGF-beta1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy
Year
2018
Function
Inhibition of miR-133b and miR-199b attenuated TGF-beta-induced epithelial-mesenchymal transition (EMT) and renal fibrosis by upregulating sirt1.